2025.12.13 [SAT] - 14 [SUN]

Science Castle World 2025

Science Tokyo, Ookayama Campus

Greetings fellow Young Researchers from Asia!

Science Castle, a conference for middle and high school students created in 2012 as a "gateway to becoming a researcher
To date, more than 15,000 junior and senior high school students have presented their research. Meet researchers who are active in society,
This year marks the 14th year of the Science Castle, which has served as a place for the next generation of researchers to leave their nests.

And 2025.
To further expand the value of the research being undertaken by the next generation of researchers and to further expand the world of Science Castle,
The first "Science Castle World" will be held.

This convention offers more opportunities for presentations and time for interaction than ever before.
More than 60 research presentations will be gathered not only from all over Japan but also from overseas, and more than 200 abstracts will be gathered at the Poster Grand Exchange, which will be joined by the adopters of the educational program at RIVANES.
In addition, a record number of special events will offer a variety of hands-on opportunities, including experimental classes and workshops by partner companies.
Moments of discussion about the appeal of research and the creation of new connections should be generated here.

This tournament is,Collaboration Agreement between Tokyo University of Science and Liverness Co.The two parties will co-sponsor the event in accordance with the
To this end, we will strengthen our collaboration with academia, including the Tokyo University of Science, and support the challenges of next-generation researchers through the participation of numerous graduate students and young researchers as "research coaches".
Corporate partners who share the philosophy of "creating the future together with the next generation of researchers" will also gather to discuss research that transcends generations and positions.

Science Castle World 2025 is,
We will enhance each individual's research perspective and develop their potential,
We aim to expand the "world" itself in which the next generation of researchers will be involved.

Whether you are already researching or want to start
Please visit the venue with genuine interest and passion in mind.
I sincerely look forward to meeting you all!

The Science Castle

Leave a Nest Co., Ltd.
Science Castle World 2025
Leader: Itsuko Kawashima

<Update
2025/09/28 Keynote Speaker Information.
2025/10/01 Dr. Maiko Matsushita, Faculty of Pharmaceutical Sciences, Keio University, was posted as a judge for oral presentations.
2025/10/21 Kihoko Tokue, Liverness Singapore, has been listed as a judge for oral presentations.

Outline of the Event

Event Name: Science Castle World 2025
Date and Time: Saturday, December 13 - Sunday, December 14, 2025
Abstract Submission: Entry deadline: Tuesday, September 30, 2025, 23:59 → Applications for 2025 are closed!
Both Japanese and English may be used for presentations. Both Japanese and English may be used in the presentation.
For information on how to apply, please contactEntry Explanation Pagefor more information.

Thank you very much for the many applications.
Notification of screening results is scheduled for early November. Notification will be sent to the e-mail address registered with your RIVANES ID.
Venue: Science Tokyo, Ookayama Campus
2-12-1 Ookayama, Meguro-ku, TokyoAccess ACCESS
Organizer: Leave a Nest Co.
Participation Fee: Presenters and observers will not be charged. Transportation and lodging to and from the venue must be paid by the individual.
Target Participants: Presenters, collaborators, school teachers, instructors, university researchers, partners, cooperating institutions, general visitors, etc.

timetable

<On the Occasion of Holding

Tokyo University of Science and Liberace have signed an MOU to promote Science Castle!
This year's Science Castle World 2025 will be held at Tokyo University of Science (ScienceTokyo), a new national university created in October 2024 through the merger of Tokyo Institute of Technology and Tokyo Medical and Dental University. A number of research coaches from the university are scheduled to participate in the event! Even if you do not plan to give a presentation, why don't you come and tour the Ookayama campus with students who are interested in Tokyo University of Science and see the graduate students and researchers of the university discussing with the next generation? For more information about the MOU between Tokyo University of Science and LIBANES, please visit(Please click here)for more information.

<Science Castle 2025 Partners (as of September 2025)

Excerpt from "Kyoiku Ouen" No. 67, 30 pages, published by LIBERNESS.

<Last year

Science Castle 2024 Tokyo-Kanto (December 7, 2024)
interpoint (interword separation)Tournament Page
interpoint (interword separation)report of implementation

Science Castle 2024 Osaka-Kansai (December 21, 2024)
interpoint (interword separation)Tournament Page
interpoint (interword separation)report of implementation

Science Castle Japan 2025 (March 22, 2025)
interpoint (interword separation)Tournament Page
interpoint (interword separation)report of implementation

Registration

Ticket to the show

If you wish to attend or observe the event,
Please click "Click here to apply for tickets to the show" below.

Click here to apply for tickets to the show

Oral Presentation

A-001 Philippines

Lara Cassandra L. Alisoso (Central Mindanao University Laboratory High School)

In Vitro Antifungal Activity of Wet Wipes Infused with MD2 Pineapple (Ananas comosus) Crown Extract Against Human Genital Candidiasis

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This study aimed to investigate the pH and antifungal activity of wet wipes infused with pineapple crown extract, as well as whether there was a Amongst all treatments, T1 and T2 demonstrated the strongest According to the findings, the three treatments with 2%, 4%, and 6% extracts performed higher antifungal activity According the findings, the three treatments with 2%, 4%, and 6% extracts performed higher antifungal activity.
A-002 Philippines

Jorace Stan Espia(University of the Philippines High School in Iloilo)

Multiple Ligand Docking of Selected Kamias (Averrhoa bilimbi L.) Flavonoids as Potential Synergistic Inhibitors to Alzheimer's Disease

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Alzheimer's Disease (AD) remains an urgent global challenge, with existing treatments offering limited efficacy and high costs. study investigates eight flavonoids from Averrhoa bilimbi L., namely myricetin, luteolin, quercetin, dihydromyricetin, catechin, apigenin, and epicatechin, as potential synergistic inhibitors of AD kaempferol, and epicatechin, as potential synergistic inhibitors of AD's major targets: acetylcholinesterase (AChE), beta-secretase 1 (BACE1), and beta-amyloid (Aβ). Using in silico multiple ligand docking and ADMET profiling, we assess their therapeutic potential. By integrating computational precision with a locally abundant plant, this research presents an innovative and cost-effective strategy toward multi-targeted, plant-based treatments that bridge By integrating computational precision with a locally abundant plant, this research presents an innovative and cost-effective strategy toward multi-targeted, plant-based treatments that bridge against neurodegeneration.
A-003 Philippines

Juliana Celestina Argana Ventura(Muntinlupa Science High School)

Antihyperlipidemic Activity on Key Lipid Biomarkers of Gumamela (Hibiscus rosa-sinensis) on Diet-Induced Diabetic Silkworms (Bombyx mori L.)

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H. rosa-sinensis (gumamela) is a plant known for its medicinal properties. this study evaluated its antihyperlipidemic potential using diet-induced This study evaluated its antihyperlipidemic potential using diet-induced diabetic silkworms (Bombyx mori), an emerging invertebrate model for metabolic research. 240 fifth-instar larvae were divided into 4 groups: standard -Diabetes was induced through a high-glucose diet, after which hemolymph samples were collected for lipid profiling. HDL, LDL, VLDL, triglycerides, and total cholesterol were measured using a lipid assay analyzer, with Friedewald Results showed significant improvements in HDL, reductions in LDL and total cholesterol, and dose- Findings suggest H. rosa-sinensis as a natural antihyperlipidemic agent and support silkworms as a viable alternative model.
A-004 Malaysia

Law En Ning(individual)

Nature Whisper: Hornbill Monitoring with Machine Learning

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This research aims to monitor hornbill distribution, with the hypothesis that machine learning can accurately detect hornbill calls. With this method, we can establish a large-scale monitoring network through mobile apps and ESP32 devices, supporting effective conservation efforts.
A-005 Japan

Tomoki Ashitani ( Tokai University Bosei Senior High School )

Form of Artificial Seagrass Bed Reefs Determined from Studies on the Behavior of Vegetable Feeding Animals

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In recent years, "isoyaki," the loss of seaweed beds, has become a problem in many parts of Japan. The same is true of the sea in Tottori, which I have visited since I was a child. The main cause of isobake in Tottori Prefecture is feeding damage caused by the sea urchins and sea eels, which are predatory animals, and I thought that seaweed beds could be restored if this problem could be solved. We will study the following two points: 1) a shape that is difficult for sea urchins to climb up and 2) a color that is repellent to sea urchins. The goal is to protect the sea of Tottori by determining a new form of substrate (the base to which seaweeds attach) based on research on the behavior of plant-eating animals.
A-006 Japan

Ayano Sasaki (St. Hilda's School)

Elucidation of the synthetic pigment transport pathway in the silkworm, Bombyx mori.

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Silkworm colored cocoons can actually only produce colorless silk threads because the colored parts fall off during the process of making the threads.
In this study, we conducted experiments of mixed feeding of various dyes and dye permeation in silk gland cells with the aim of producing colored silk threads, and found that the transport was not passive diffusion.
Future research will focus on the chemical structure of the pigment, staining ability, solubility, and silkworm metabolism in order to elucidate the cause of the disease.
A-007 Japan

Yuto Shigeta (Osaka Prefectural Tondabayashi Senior High School)

Study of the ecology of the striped reed warbler in the Ishikawa River watershed of the Yamato River system.

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The ecology of the striped reed warbler is still largely unknown, and this study aimed to elucidate it. A survey was conducted in the Ishikawa watershed, and results showed high density in reservoirs and locally in the Ishikawa. One case of spawning and hatching was observed in a tank, and the eggs and hatchlings were extremely small. Stomach contents of individuals collected in the reservoir indicated that they preyed on fish. Since we observed cannibalism among fry in the tanks, we hypothesized that the emergence of fry often seen in the reservoir was to escape cannibalism.
A-008 Japan

Shinri Suzuki (Kosei Gakuen Senior High School)

Developing an AI that can understand emotions specifically for hospitalized middle and high school students

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Based on the hypothesis that "in addition to textual information, non-verbal information can be input to AI to realize more empathetic and cohesive responses," we developed an AI service that specifically addresses the concerns of hospitalized junior and senior high school students. One of the novelties of this development was the integration of FACS, a facial expression analysis system, with LLM, a domain of natural language processing. This enabled LLM to change its response according to changes in the user's emotions, in addition to the conventional text-based communication.
A-009 Japan

Nana Tamaki (Mita International School of Science)

Aiming for reduced chemical fertilizer agriculture by utilizing Euglena in hydroponics

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Japanese agriculture has become unstable due to soaring fertilizer prices and dependence on imports, and chemical fertilizer supply risk and environmental impact are particularly problematic. In this study, an amino acid fertilizer derived from euglena was developed to improve the efficiency of hydroponic cultivation and reduce nitrogen fertilizers. The growth-promoting effect of the extract was demonstrated, and the possibility of partially replacing existing fertilizers was confirmed through factor analysis and hydroponic tests. This presented a new strategy that contributes to chemical fertilizer reduction, cost reduction, and environmental impact reduction.
A-010 Japan

Sarina Tsuchiya (Hoshinomori Senior High School)

Modeling schizophrenia using canonical neural circuits

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The purpose of this study was to investigate whether the symptoms of schizophrenia could be explained as an attenuation of reasoning due to abnormalities in neural circuitry. Conventional research methods did not allow cell-by-cell studies. Therefore, I constructed a model based on the free energy principle and hypothesized prior belief bias and abnormalities in the giant spine. As a result, I succeeded in reproducing symptoms in three tasks, and demonstrated the possibility of gaining a deeper understanding of schizophrenia in a computational manner without using actual brains.
A-011 Japan

Miharu Maekawa (Ibaraki Prefectural Namiki Secondary School)

Development of a wearable battery that generates electricity from sweat

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The purpose of this study was to produce a "usable" sweat battery for mounting experiments. As hypotheses, we optimized the combination of metals and resistance, examined the conditions of artificial sweat solution and contact materials, and evaluated the battery through mounting experiments. As a result, the demonstration experiment confirmed that the battery is capable of generating electricity from actual sweat. Furthermore, lactic acid concentration, pressure, and material affected the amount of power generated, and sodium chloride showed stable power generation. As a result of the discussion, issues for practical application were clarified by improving electrode conditions and materials.
A-012 Japan

Rico Fukuda (Kanagawa Prefectural Kawawa Senior High School)

Can EAA Contribite to the Welfare of Horses?

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The psychological effects of horse-mediated activities on horses were examined in terms of physiological and behavioral indices. The results of this study showed a significant decrease in heart rate and cortisol in horses after the activity, a significant decrease in stress-related behaviors, and a significant increase in relaxation-related behaviors. It was shown that under appropriate management, horse-mediated activities have a positive, not stressful, impact on the horses that contributes to improved welfare.

Oral Presentations Judges

Shuichiro Takahashi (Head of Jury)
Leave a Nest Co., Ltd.
　Representative Director, President and COO
Doctor of Life Sciences

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After graduating from Tokyo Institute of Technology (now Tokyo University of Science), he completed his doctoral studies at the Graduate School of Frontier Sciences, The University of Tokyo. D. in Life Sciences. Founding member of RIVANESS. He established the research institute of RIVANESS and built the foundation for research support and R&D projects. He has devised unique business models such as "RIVANESS Research Fund" and "L-RAD," a platform for unused research ideas, and has led many projects involving industry, academia, and education.
Kihoko Tokue
Director Leave a Nest Singapore Pte. Ltd.
Head of Institute Leave a Nest Group Education Research Institute
Doctor of Science

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D. in ecological research after growing up in Japan, Thailand, Singapore, Australia, and the U.S. After joining LIVERNESS in 2011, he established the International Development Division and established a Malaysia/Singapore corporation, developed TECH PLANTER and Science Castle in ASEAN, and promoted international collaboration in education and research, In October 2025, he was appointed as Director of the Education Research Center to accelerate education research and development in Asia.
Maiko Matsushita
Faculty of Pharmaceutical Sciences, Keio University
　Professor, Department of Pathophysiology
Doctor of Medicine

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After graduating from Keio University School of Medicine in 1995, he joined the Department of Internal Medicine at Keio University Hospital and completed the graduate course at Keio University Graduate School of Medicine in 2000. He has been working on the development of novel cancer immunotherapies using artificial T cells and naturally-derived compounds for refractory cancers as a full-time lecturer in the Department of Pathophysiology, Faculty of Pharmaceutical Sciences at Keio University since 2010, an associate professor in 2015, and a professor in 2024.
Takuji Yamada
Tokyo University of Science
Associate Professor, School of Bioscience and Biotechnology
Doctor of Science

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D. in 2006 from the Graduate School of Science, Kyoto University. D. in Science. D. in 2006 from the Graduate School of Science, Kyoto Institute of Technology. He is a recipient of the 2020 Minister of Education, Culture, Sports, Science and Technology Award for Science and Technology (Research Category). He specializes in life information science.

keynote speech

Array, Hiroyuki Ota, CEO, Phytolipid Technologies, Inc.<br />Science Tokyo Emeritus professor<br />

Dr. Hiroyuki Ohta

Pytolipid Technologies Co., Ltd. Chief Executive Officer
Science Tokyo Emeritus professor

Using Up the Power of Photosynthesis - Future Resources Produced by Algae from Carbon Dioxide

Nannochloropsis, an algae, uses photosynthesis to capture carbon dioxide from the atmosphere and produce lipids, one of the materials that support our daily lives. Based on the knowledge that has revealed the mechanism of effective utilization of carbon dioxide through photosynthesis at the molecular level, I will talk about the challenge to change the world with the power of algae.

＜プロフィール＞

D. in Agriculture, Graduate School of Agriculture, Kyoto University. D. in Agriculture. After working as a researcher at Mitsui Plant Bio Research Institute and a cooperative researcher at National Institute for Basic Biology, he started his research on plant lipid science at Tokyo Institute of Technology in 1991. His goal is to explore the synthesis and metabolic mechanisms of lipids in plants and algae at the molecular level, and to realize sustainable resource recycling through their application.